Research & Development

Research & Development

In developing countries contaminated food, water, unsanitary environment and unhygienic manner of living, due to illiteracy and consumption of alcohol are some of the causes of liver ailments. These ailments include Jaundice, Hepatitis, Cirrhosis of liver which result into anorexia, mild fever, nausea and vomiting, oedema on foot, pruritus, debility, anemia and constipation.

Today, a large number of drugs are available for providing relief in liver disorders, but it is certain that modern drugs are inadequate in the treatment. However, the traditional Indian Ayurvedic system has the possibility of offering reliable, effective and affordable options with no side effects on the human body.

LIVBY, a traditional herbo-mineral recipe (invented by Late Shri Vimal Kumar), is a revolutionary invention in this category and a fast-acting powerful hepatic stimulant which increases the functional capacity of liver, accelerates cellular metabolic activity and promotes liver cells regeneration. A patented intellectual property, LIVBY is supported by extensive research work with encouraging results. The details are as under:-
  

  1. Research paper in Medical Journal of Toho University Japan. A research paper on LIVBY by Dr Kaushal Kumar and Dr Vinod Upadhyay of Gurukul Kangri University, Haridwar was published in medical Journal of Toho University, Japanin 1994. The highlights of the research work mentioned in the paper are as under:
(a) The chemical examination and lab findings revealed the presence of Sodium, Potassium, Calcium, Phosphorus, Chloride, Sulphate, Iron and Citric acid.
(b) These minerals are essential for the proper functioning of the body and form a constituent of all extracellular fluids, various digestive juices, inorganic salts of bile and tissues notable to the nerves, blood and muscles. An effective medicine prepared from natural sources, should therefore find high level of acceptance for patients of hepatic disorders.
(c) The recipe hasno risk of toxicity which is carried by the modern drugs to the human system. The herbal ingredients are safe like the milk and food, easily available in the tropical countries from natural sources. The recipe will help:
(i) To keep electrolyte balance in dehydration.
(ii) To safeguard the liver against toxicity of chemical based synthetic drugs.
(iii)In anemia, jaundicedue to its ingredients effective and essential in the disorder of Haemopoietic system.
(iv)InViral fever, Dengue fever (the recovery was very fast, probably it provides an impetus to the immune system of the body).
(v) Due to its effect on promoting the immune system of the body,it may be an adjunct to the patients of AIDS, Tuberculosis and Cancer. 


 

  1. The Preclinical Study (Scientific validation of safety, protective and   curative efficacy of LIVBY for Liver disorders) at Sri Ram Chandra  University, Chennai.During year 2012-15, the Ministry of Science & Tech,   Govt of India granted research funds to formally test the safety of LIVBY in   animal models. The research was carried out by Dr Sarvana Babu      Chidambaram at Sri Ramchandra University, Chennai. Highlights of the  research are as under:-
(a) Phytochemical analysis revealed the presence of phenolic compounds, tannins, glycosides, sugars, alkaloids and flavonesin LIVBY   
(b) LIVBY is/was: -
(i)  Found to contain Vitamin C (1.34±0.04 µg/ml) and Citric acid (6.4 ±0.54 µg/ml).
(ii)  Potent free radicals’ scavenger (determined using DPPH, super oxide, lipid peroxide, nitric oxide and H2O2 radical’s assays).
(iii) Free from heavy metalssuch as lead [Pb], Cadmium [Cd], Mercury [Hg] and Arsenic [As].
(iv) Tested for its safety in rat model and wasfound to be non-toxic at the tested concentrations when administered in male and female rats (1000 mg/kg, p.o for 90 days). LIVBY also found to protect liver against alcohol, drug (paracetamol) and chemical (carbon tetrachloride) induced toxicity.

 

  1. Study on Hepatoprotective effect of LIVBY (in Paracetamol, Ethanol and Methotrexate induced toxicity in Chang liver cells) at JSS College of Pharmacy, Mysuru.The exact molecular mechanism of liver protection effects of LIVBY was also studied during year 2018-19, using drugs (paracetamol; methotrexate -anti-cancer) and alcohol induced liver damage using liver cells directly. The study was carried out by Dr Saravana Babu Chidambaram at JSS College of Phatmacy.

 

  1. Special Achievements. The most highlighting achievement of LIVBY is that it possesses two patents the Process Technique (Patent No 239637, CGPDTM, Ministry of Commerce and Industry, Govt of India) and the Product Patent (Patent no 355653, Intellectual Property of India, Govt of India) with a title ‘A Synergistic and Non-toxic combination for treating Liver Disorders.